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If the connectivity seems OK but you have an application, e.g. your TIE, which is not working correctly, you might like to try a direct connection from the command line using curl. This will help to narrow down where the problem lies. For example, the following is a simple QRY A19 which asks for a maximum of 1 patient records to be returned. Although in theory any HL7 message could be used, the benefit of a query message is that you do not need to send any data to your patient records to confirm the connection.
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