If going through our checklist does not help to resolve your connectivity issue, please supply the information below when reporting an issue to our support desk:
IP address of the machine where error was observed.
or NAT egress IP as that service appears to outside of your organization.
Integration engine parameters:
Supported TLS versions
Supported cipher suites
Trusted Root CA certs
Target hostname and/or IP you're trying to connect to.
Exact symptom (a stack trace ideally).
This information will help us to troubleshoot the causes of your issue more quickly.